ABSTRACT
The tribe Chelidonieae comprises 23 species of eight genera with an extensive distribution and a long medicinal usage history both in China and Western countries. A large number of chemical constituents have been isolated and identified from the species in tribe Chelidonieae, such as alkaloids, organic acids, and their derivatives, aromatics, triterpenoids, sterols, essential oils, and proteins, most of which possess a variety of bioactivities, especially for the antibacterial, anti-inflammation, antitumor, analgesia, anti-oxidation, and antiparasitic activity. Meanwhile, potential toxicities have been discovered in some constituents. Therefore, the species in tribe Chelidonieae have become a rich source for new drug discovery, biologic study, and mechanism research. This paper presents comprehensive information of the chemical constituents, pharmacological and toxicological research on the plants in tribe Chelidoieae, which is a reference for the plants in this tribe for further development. © 2014 Tianjin Press of Chinese Herbal Medicines.
ABSTRACT
In order to find the cardiotonic constituents of lateral roots of Aconitum carmichaelii Debx., the investigation was carried out. Silica gel column chromatography, Sephadex LH-20, medium-pressure MCI and reverse phase ODS column chromatography were used to separate the 90% EtOH extract of the lateral roots of Aconitum carmichaelii Debx. The structures of the isolated compounds have been identified by chemical properties and spectroscopic analyses. Ten compounds were isolated and their structures were elucidated as benzoic acid-5-hydroxy-2-benzoyl-amino methyl ester (1), honokiol (2), pinoresinol (3), salicylic acid (4), p-hydroxy-cinnamic acid (5), songorine (6), karakoline (7), mesaconitine (8), hypaconitine (9) and 14-benzoylhypaconitine (10), separetely. Compound 1 is a new compound and its structure has been established by NMR, HR-ESI-MS, UV, IR and X-Ray. Compound 2-5 are isolated from the lateral roots of Aconitum carmichaelii Debx. for the first time.
Subject(s)
Aconitum , Chemistry , Cardiotonic Agents , Chemistry , Plant Roots , ChemistryABSTRACT
Objective: To investigate the chemical constituents of Aconiti Lateralis Radix Praeparata. Methods: The constituents were isolated by silica gel, neutral alumina, Sephadex LH-20 gel, and medium-pressure MCI columns, and their structures were identified by chemical properties and spectroscopic analyses. Results: Eighteen compounds were isolated and their structures were elucidated as mesaconitine (1), aconitine (2), hypaconitine (3), 14-benzoylhypaconitine (4), 14-benzoylmesacontine (5), 14-benzoyaconitine (6), chasmanine (7), talatisamine (8), neoline (9), karakoline (10), fuziline (11), songorine (12), isotalatizidine (13), senbusine B (14), 16β-hydroxycardiopetaline (15), columbianine (16), benzoic acid (17), and 6-hydroxymethyl-3-pyridinol (18). Conclusion: Compounds 15-18 are obtained from this plant for the first time.
ABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents contained in ethanol extracts from aerial parts of Emilia sonchifolia.</p><p><b>METHOD</b>The compounds were separated and purified with various chromatographic techniques, and their structures were identified on the basis of physicochemical properties and spectral data.</p><p><b>RESULT</b>Fifteen compounds were separated from ethyl acetate fraction of 90% ethanolic extract and identified as rhamnetin (1), isorhamnetin (2), quercetin (3), luteolin (4), tricin-7-O-beta-D-glucopyranoside (5), 8-(2"-pyrrolidinone-5"-yl) -quercetin (6), 5, -2', 6'-trihydroxy-7, 8-dimethoxyflavone-2'-O-beta-D-glucopyranoside (7), succinic acid (8), fumaric acid (9), p-hydroxybenzoic acid (10), 4-hydroxy isophthalic acid (11), 3, 4-dihydroxycinnamic acid (12), esculetin (13), isowedelolactone (14) and uracil (15), respectively.</p><p><b>CONCLUSION</b>All compounds except compound 3 were separated from this genus for the first time.</p>